This article presents evidence from archival sources that allows us to reconstruct the commercial networks that permitted the continuous flow of silver and gold from northern New Spain to Asia during the early modern era. These networks obtained various consumer goods – fabrics, spices, porcelain – that were then introduced into Spanish American markets. The narrative follows the bullion through its journey from the production center in San Luis Potosi to the Pacific and Asia. This vantage point contributes to the construction of a polycentric view within the framework of global history by assessing the role played by the American and Asiatic possessions of the Hispanic Empire in the first globalization. Using a methodological framework provided by social network analysis, the article presents a study of two commercial networks based in New Spain and extending to the Philippines and Peru. The essay underlines the role merchants played in mobilizing precious metals to accelerate exchanges and generate extraordinary profit margins.